KMID : 0360220180590030238
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Journal of the Korean Ophthalmological Society 2018 Volume.59 No. 3 p.238 ~ p.245
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Long-term Treatment Outcome of Intravitreal Aflibercept Monotherapy for Polypoidal Choroidal Vasculopathy
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Kim Ye-Ji
Han Sang-Youn Kim Jong-Woo Kim Chul-Gu Lee Dong-Won Kim Jae-Hui
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Abstract
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Purpose: To evaluate long-term treatment outcomes of intravitreal aflibercept monotherapy for polypoidal choroidal vasculopathy (PCV).
Methods: A retrospective review of medical records was performed with 46 patients who were diagnosed with PCV and treated with aflibercept monotherapy for 24 months. Best-corrected visual acuity (BCVA) values measured at diagnosis, 3 months, 12 months, and 24 months were compared. Baseline morphological factors associated with the 24 month BCVA were additionally investigated.
Results: The mean age of the patients was 65.8 ¡¾ 7.9 years. The patients were treated with a mean of 7.0 ¡¾ 2.3 aflibercept injections. The mean logarithm of the minimal angle of resolution (logMAR) BCVA at diagnosis, 3 months, 12 months, and 24 months was 0.56 ¡¾ 0.40, 0.36 ¡¾ 0.36, 0.45 ¡¾ 0.42, and 0.52 ¡¾ 0.47, respectively. When compared with baseline values, the BCVA was significantly improved at 3 months (p < 0.001) and 12 months (p = 0.022). However, the value at 24 months was not significantly different (p = 1.000). The BCVA was improved or maintained in 35 eyes (76.1%). Extrafoveal polypoidal lesions were associated with a better 24 month visual outcome than subfoveal/juxtafoveal lesions.
Conclusions: Aflibercept monotherapy was found to be an effective method to maintain or improve long-term visual acuity in PCV patients. The location of polypoidal lesions was a predictive factor for long-term visual outcomes
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KEYWORD
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Aflibercept, Age-related macular degeneration, Choroidal neovascularization, Long-term, Polypoidal choroidal vasculopathy
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